Journal of the Microelectronics and Packaging Society (마이크로전자및패키징학회지)

The Korean Microelectronics and Packaging Society (한국마이크로전자및패키징학회)
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Development and Packaging of Multi-channel Imaging Module for Near-infrared Fluorescence Imaging System

근적외선 형광 영상 시스템용 다채널 영상 모듈 개발 및 패키징

  • 김태훈 (부산대학교 인지메카트로닉스공학과) ;
  • 서경환 (나우비젼 주식회사) ;
  • 이학근 (나우비젼 주식회사) ;
  • 정명영 (부산대학교 인지메카트로닉스공학과)
  • Received : 2019.06.15
  • Accepted : 2019.06.27
  • Published : 2019.06.30
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Abstract

In this paper, we introduced a near-infrared multi-channel fluorescence imaging system and analyzed the effects of measurements variables such as exposure time, working distance and intensity of excitation light. Fluorescence signal is increased as exposure time becomes longer, excitation light intensity increases or working distance becomes smaller. Furthermore, the proper composition of optical filters and precise packaging of the imaging modules prevent the increase of background signal. Thus, we confirmed an increase in SBR. Based on the result of this research, we proposed a method to use a multi-channel fluorescence imaging system.

본 논문에서는 근적외선 다채널 형광 영상 시스템을 소개하고, 노출시간, 작동거리, 여기광의 강도에 따른 형광 영상 시스템의 특성에 대해 분석하였다. 노출시간이 길수록, 작동거리가 짧을수록, 여기광의 강도가 강할수록 형광신호가 증가하였다. 필터의 적절한 구성과 영상 모듈의 정밀한 패키징으로 배경신호의 증가를 억제하여 SBR이 증가하는 것을 확인하였다. 본 연구의 결과를 바탕으로 다채널 형광 영상 시스템을 활용할 수 있는 방안에 대해 제안하였다.

Keywords

MOKRBW_2019_v26n2_59_f0001.png 이미지

Fig. 1. Schematic diagrams of a multi-channel fluorescence imaging system using (a) 3 separate cameras, (b) a 2-CCD multi-spectral camera and a monochrome NIR camera.

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Fig. 2. Schematic diagrams of (a) a multi-channel fluorescence imaging system using a 3-CCD camera, and (b) the prism block of system (a).

MOKRBW_2019_v26n2_59_f0003.png 이미지

Fig. 3. (a) SBR according to the excitation laser current, (b) the captured images, (c) the area used to calculate the SBR and (d) color image with scale bar(left), merged image of color and fluorescence image when current is 1.2A(right).

MOKRBW_2019_v26n2_59_f0004.png 이미지

Fig. 4. (a) SBR according to exposure time of the NIR camera, (b) the captured images at a constant WD of 30 cm and a laser current of 1.0 A.

MOKRBW_2019_v26n2_59_f0005.png 이미지

Fig. 5. (a) SBR according to working distance, (b) the captured images at a laser current of 1.0 A and 10 ms of exposure time for the NIR camera.

Table 1. Fluence rate relative to the laser diode current

MOKRBW_2019_v26n2_59_t0001.png 이미지

References

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