Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Biodegradable Inorganic-Organic Composite Artificial Bone Substitute

  • Suh, Hwal (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Lee, Jong-Eun (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Ahn, Sue-Jin (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Lee, Choon-Ki (Department of Orthopaedic Surgery, College of Medicine, Seoul National University)
  • Published : 1995.03.01
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Abstract

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased.

Keywords

References

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