Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Combined Effect of Korean Red Ginseng and EGb 761 on Ultraviolet B-induced Contact Hypersensitivity

UV-B조사로 유도된 접촉 과민반응에 대한 홍삼과 홍삼+EGb 761 혼합물의 억제 효과 비교

  • Choi Wookhee (Department of Health Science, Dongduk Women's University) ;
  • Kim Duksung (Department of Health Science, Dongduk Women's University) ;
  • Ann Hyoungsoo (College of Pharmacy, Dongduk Women's University) ;
  • Lee Youngmi (College of Pharmacy, Dongduk Women's University) ;
  • Ahn Ryoungme (Department of Health Science, Dongduk Women's University)
  • 최욱희 (동덕여자대학교 보건관리학과) ;
  • 김덕성 (동덕여자대학교 보건관리학과) ;
  • 안형수 (동덕여자대학교 약학대학) ;
  • 이영미 (동덕여자대학교 약학대학) ;
  • 안령미 (동덕여자대학교 보건관리학과)
  • Published : 2005.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Exposure of skin to UV-B radiation can cause inflammatory response and immunosuppression. It has been reported that Korean Red Ginseng (KRG) has several pharmacological and physiological effects such as antioxidant, anticancer and improving immune function. In this study, we investigated that topical KRG and KRG + EGb 761 (Ginkgo biloba extract) combination prevented UV-B induced inflammation and inhibition of contact hypersensitivity response. Topical application of KRG, f days prior to or 5 days after exposure to 1MED and 2MED of UV-B, reduced skin thickness compared to non -treated group and resulted in protection against immunosuppression. However, KRG+EGb 761 combination has a little protection against the only 1MED UV-B. In conclusion. Topical application of KRG was more effective than combination in protection against UV-B induced inflammation and immune suppression. Also, we suggest that KRG can provide protection from inflammation and immunosuppression by UV-B radiation.

Keywords

References

  1. 김태영, 이청무. 홍삼투여가 운동시 항산화효소 및 과산화 지질의 변화에 미치는 영향. 한국운동과학회지. 1999; 8(3): 473-483
  2. 곽이성, 박종대, 양재원. 홍삼효능 연구의 최근 현황과 그 전망. 식품산업과 영양. 2003; 8(2): 30-37
  3. 성금수, 전 철, 권용훈, 김경현, 장재철. 홍삼 추출물 투여가 생쥐간에서 항산화 효소 활성과 지질과산화에 미치는 효과. 고려인삼학회지. 2000; 24(1): 29-34
  4. 윤재일. Effect of ultraviolet radiation on the skin., J. Korean Asso. Radiat. Prot., 1995; 20(3): 181-186
  5. 이은희, 이종권, 홍진태, 정경미, 김용규, 이선희, 정수연, 이용욱. 녹차추출물 성분 catechin이 자외선에 의해 손상된 피부에 미치는 영향. J. Fd Hyg. Safety. 2001; 16(2): 117-124
  6. 이청무. 홍삼과 비타민 E 투여가 혈중 항산화효소 활성도 및 과산화지질 생성에 미치는 영향. 체육학회지. 2000; 39(1): 476-488
  7. 이화재, 김동윤, 장재철. Paraquat 투여 생쥐 간에서 홍삼 추출물이 항산화효소 활성과 지질과산화에 미치는 항산화 효과. 고려인삼학회지. 1999; 23(3): 182-189
  8. 이혜연, 이한수. 홍삼 추출물의 임파구 증식 및 활성 촉진 효과. 고려인삼학회지. 1998; 22(1): 60-65
  9. 장성강, 김주헌, 정윤신, 안동춘, 강명재, 이동근, 김상호. 한국 홍삼의 면역활성 및 항암효과에 관한 실험적 연구. 고려인삼학회지. 1994; 18(3): 151-159
  10. 장재철, 김동조. 홍삼사포닌이 노화촉진 생쥐 간 조직에서의 Superoxide Dismutase 활성과 지질과산화에 미치는 영향. 기초과학회지. 1994; 9: 57-64
  11. 전 철, 장재철, 홍삼 투여가 방사선에 조사된 생쥐 간세포의 Superoxide Dismetase, Peroxide 및 Catalase 활성도에 미치는 영향. 고려인삼학회지. 1993; 17(1): 29-34
  12. 최욱희, 안형수, 안령미. ICR mouse에 있어 UVB 조사로 유도된 접촉 과민반응에 대한 EGb 761의 억제 효과. 한국환경보건학회지. 2005; 31(1): 7-14
  13. Baumann L. Cosmetic Dermatology. 정담미디어. 2004
  14. Bissette DL, Chatterjee R and Hannon DP. Photoprotective effect of superoxide-scavenging antioxidants against ultraviolet radiation-induced chronic skin damage in the hairless mouse. Photodermatol. Photoimmunol. Photomed. 1990; 7: 56
  15. Diplock AT, XU G, Yeow C. et al. Relationship of tocophe¬rol structure to biological activity, tissue uptake, and prostaglandin synthesis. In: Diplock AT, Machlin LJ, Packer L. et al., eds: Vitamin E: Biochemistry and Health Implications. New York, New York Academy of Sciences, 1989
  16. Fazekas Z, Gao D, Saladi RN, Lu Y, Lebwohl M and Wei H. Protective effects of lycopene against ultraviolet Binduced photodamage. Nutr. Cancer. 2003; 47(2): 181-187 https://doi.org/10.1207/s15327914nc4702_11
  17. Han SK, Song JY, Yun YS and Yi SY. Ginsan improved Th1 immune response inhibited by gamma radiation. Arch Pharm Res. 2005; 28(3): 343-350 https://doi.org/10.1007/BF02977803
  18. Ichihashi m, Ueda M, Budiyanto A, Bito T, Oka M et al. Uv-induced skin damage. Toxicology. 2003; 189: 21-39 https://doi.org/10.1016/S0300-483X(03)00150-1
  19. Jang SK, Kim JH, Chung YS, Ahan OC, Kang M, Lee DK and Kim SK. An experimental study on the effect of immunopitiential and anticancer effect of red ginseng extract. Korean J. Ginseng Sci. 1994; 18: 151-159
  20. Katiyar SK. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects. Int. J. Oncol. 2005; 26(1): 169-176
  21. Kripke ML. Photoimmunology. Photochem. Photobiol., 1990; 52: 919-924 https://doi.org/10.1111/j.1751-1097.1990.tb08703.x
  22. Larsen MW, Moser C, Hoiby N, Song Z and Kharazmi A. Ginseng modulates the immune response by induction of interleukin-12 production. APMIS. 2004; 112(6): 369-373 https://doi.org/10.1111/j.1600-0463.2004.apm1120607.x
  23. Lazzarini M, Salum C and Del Bel EA. Combined treatment of ascorbic acid or alpha-tocopherol with dopamine receptor antagonist or nitric oxide synthase inhibitor potentiates cataleptic effect in mice. Psychopharmacology (Berl). 2005; 2: Epub ahead of print
  24. Nakamura T, Pinnell SR, Darr D, Kurimoto I, Itami S, Yoshikawa K and Streilein JW. Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-alpha. J Invest Dermatol. 1997; 109(1): 20-24 https://doi.org/10.1111/1523-1747.ep12276349
  25. Nishiyama N, Zhou Y and Hiroshi S. Ameoliorative effects of chronic oral treatment using DX-9386, a traditional Chinese prescription, on learning performances and lipid peroxide content in senescence accelated mouse. Biol Pharm Bull. 1994; 17: 1481-1484 https://doi.org/10.1248/bpb.17.1481
  26. Petkov VD, Kehaypv R, Konstantinova E, Petov VV and Getov D. Ginkgo and their combination Gincoan (PHK-00701). Planta Medica. 1994; 59: 106-114
  27. Shen JG and Zhou DY. Efficiency of Ginkgo biloba extract (EGb 761) in antioxidant protection against myocardial ischemia and reperfusion injury. Biochem Mol Biol Int. 1995; 35(1): 125-34
  28. Tanaka S, Sato T, Akimoto N, Yano M and Ito A. Prevention of UVB-induced photoinflammation and photoaging by a polymethoxy flavonoid, nobiletin, in human keratinocytes in vivo and in vitro. Biochem. Pharmacol. 2004; 68(3): 433-439 https://doi.org/10.1016/j.bcp.2004.04.006
  29. Trevithick JR, Xiong H, Lee S et al. Topical tocopherol acetate reduces post-UVB, sunburn-associated erythema, edema, and skin sensitivity in hairless mice. Arch Biochem. Biophys. 1992; 296: 575 https://doi.org/10.1016/0003-9861(92)90613-2
  30. Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T and Rui H. Cancer chemopreventive and therapeutic activities of red ginseng. J. Ethnopharmacol. 1998; 60(1): 71-78 https://doi.org/10.1016/S0378-8741(97)00133-5
  31. Zaidi SM, AL-Qirim TM and Banu N. Effect of antioxidant vitamins on glutathione depletion and lipid peroxidation induced by restraint stress in the rat liver. Drug R D. 2005; 6(3): 157-165 https://doi.org/10.2165/00126839-200506030-00004