Journal of Sensor Science and Technology (센서학회지)

The Korean Sensors Society (한국센서학회)
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Microfluidic chip for characterization of mechanical property of cell by using impedance measurement

임피던스 측정을 이용한 세포의 변형성 분석용 미소유체 칩

  • Kim, Dong-Il (Department of Electronic Engineering, Sogang University) ;
  • Choi, Eun-Pyo (Department of Mechanical Engineering, Sogang University) ;
  • Chio, Sung-Sik (School of Life Science and Biotechnology, Korea University) ;
  • Park, Jung-Yul (Department of Mechanical Engineering, Sogang University) ;
  • Lee, Sang-Ho (School of Life Science and Biotechnology, Korea University) ;
  • Yun, Kwang-Seok (Department of Electronic Engineering, Sogang University)
  • Published : 2009.01.31
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Abstract

In this paper we propose a microfluidic chip that measures the mechanical stiffness of cell membrane using impedance measurement. The microfluidic chip is composed of PDMS channel and a glass substrate with electrode. The proposed device uses patch-clamp technique to capture and deform a target cell and measures impedance of deformed cells. We demonstrated that the impedance increased after the membrane stretched and blocked the channel.

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References

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