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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Effects of Ethanol Extract of the Rhodiola Sachalinensis for Anti-oxidation and Blood Pressure and Skeletal Muscles Contractility in Rat

고산흥경천 에탄올 추출물의 항산화작용과 쥐의 혈압 및 골격근 수축성에 미치는 영향

  • Jin, Yinzhe (College of Food Science and Technology, Shanghai Ocean University) ;
  • Cheng, Yu-dong (College of Food Science and Technology, Shanghai Ocean University) ;
  • Lee, Kwang-Jin (College of Pharmacy, University of Hawaii) ;
  • Jung, Yong-An (Meter and Petrochemical Testing and Research Institute) ;
  • Row, Kyung-Ho (Department of Chemical Engineering, Inha University)
  • 김은철 (상해해양대학 식품학원) ;
  • 청위동 (상해해양대학 식품학원) ;
  • 이광진 (하와이대학교 약학대학) ;
  • 정용안 (한국기기유화시험연구원) ;
  • 노경호 (인하대학교 화학공학과)
  • Received : 2011.01.01
  • Accepted : 2011.04.26
  • Published : 2011.06.30
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Abstract

To study the effects of ethanol extract of the Rhodiola Sachalinensis on the anti-oxidation and blood pressure and skeletal muscles contractility in rats. The ethanol extracts and fractions of Rhodiola Sachalinensis were determinated the anti-oxidation effects by DPPH(1,1-dipenyl-2-picrylhydrazyl) method and comparing with the BHA (Butylated hydroxyanisole) and AA(Ascorbic acid). The gastrocnemius and soleus muscle contractility were observed by stimulating the sciatic nerve with electricity after affusing stomach with ethanol extract of the 200 mg/kg dosage of Rhodiola Sachalinensis for 4 weeks. The ethanol extract of the Rhodiola Sachalinensis could shorten latent period, increase maximal contractive extent and time and relaxative time at the twitch and complete tetanus of gastrocnemius and soleus muscles. The ethanol extract of the Rhodiola Sachalinensis shows high anti-oxidation effect and can enhance skeletal muscles contractility in rats.

Keywords

References

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