The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Antistress effect of Gagamsanzointang on rat chronic stress model

가감산조인탕(加減酸棗仁湯)이 만성 스트레스 모델 쥐에 대한 항스트레스 효과

  • Kwon, Hyuk-Jin (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Kim, Kyeng-Sub (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Kang, Su-Kueng (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Park, Pil-Sang (National Institute of Horticultural and Herbal Science) ;
  • Yu, Ji-Yeon (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Lim, Ji-Min (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Cho, Yong-Sik (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Choi, Yoon-Hee (Fermentated Food Science Division, National Academy of Agricultural Science, RDA) ;
  • Park, Shin-Young (Fermentated Food Science Division, National Academy of Agricultural Science, RDA)
  • 권혁진 (국립농업과학원 발효식품과) ;
  • 김경섭 (국립농업과학원 발효식품과) ;
  • 강수경 (국립농업과학원 발효식품과) ;
  • 박필상 (원예특작과학원 인삼가공팀) ;
  • 유지연 (국립농업과학원 발효식품과) ;
  • 임지민 (국립농업과학원 발효식품과) ;
  • 조용식 (국립농업과학원 발효식품과) ;
  • 최윤희 (국립농업과학원 발효식품과) ;
  • 박신영 (국립농업과학원 발효식품과)
  • Received : 2012.10.13
  • Accepted : 2012.11.06
  • Published : 2012.11.30
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Abstract

Objectives : To observe the effect of 4 kinds of Korean medicine and complex extracts on the anti-stress of chronic mild stress Rat model, so as to find out the machanism of its pharmacological effects. Methods : 64 healthy SD Rats were randomly divided into 8 groups. Model Design by chronic stress(CSM), and carried out the forced swimming test. We investigated the body weight, feed and water intake, feed conversion ratio and measured parameters to changes in swimming time, immobility time, 2 and 24 hours of feces, corticosterone hormone and blood glucose level. Results : In this experiments, body weight gain and feed intake were higher in all korean medicinal herb group. Swimming time were increased by Zizyphus jujuba and Gagamsanzointang(SZT) groups and immobility time was significantly lower by Zizyphus jujuba and Fluoxetine(FLX) groups. The result of corticosterone hormone level were significantly lower in Fluoxetine(FLX) and Gagamsanzointang(SZT) but blood glucose was not significantly difference. In 2 hours after fecal frequency result were significantly lower in Zizyphus jujuba group. but SZT group were increased. This result caused by acute stress but 24 hours of feces were restored to normal. Conclusions : 5 kind of Korean Medicinal Herbs extracts has good anti-stress effects, and also to clear the circulatory system and regulate blood glucose and improve bowel function. We suggest that use a single Korean medicine rather than the combination to relieve stress.

Keywords

References

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