KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Characteristics of Growth, Pigment and Monacolin K Production by Monascus strains in Liquid Culture

액체배양에서의 홍국균의 생장, 색소 및 monacolin K 생산 특성

  • Seo, Jin-Won (Department of Applied Bioscience, CHA University) ;
  • Kim, Chang Sup (Department of Chemical and Biological Engineering, Hanbat National University) ;
  • Seo, Eun Jeong (Department of Applied Bioscience, CHA University) ;
  • Jeon, Che Ok (Department of Life Science, Chung-Ang University) ;
  • Choi, Hyung-Kyoon (College of Pharmacy, Chung-Ang University) ;
  • Park, Youn-Je (Department of Applied Bioscience, CHA University)
  • 서진원 (차의과학대학교 바이오공학과) ;
  • 김창섭 (한밭대학교 화학생명공학과) ;
  • 서은정 (차의과학대학교 바이오공학과) ;
  • 전체옥 (중앙대학교 생명과학과) ;
  • 최형균 (중앙대학교 약학대학) ;
  • 박윤제 (차의과학대학교 바이오공학과)
  • Received : 2012.10.03
  • Accepted : 2012.10.26
  • Published : 2012.10.31
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Abstract

The hyphal growth, production of color pigments and monacolin K by Monascus strains were investigated in liquid medium. Thirty five different strains were collected and cultured in potato dextrose yeast extract broth (PDYB), potato dextrose broth (PDB) and malt extract broth (MEB) medea at $25^{\circ}C$ for 7 days. The growth rates of most of strains were highest in PDYB medium. Growth rate as well as pigment production were influenced by suspension conditions of mycelia during liquid cultivation. Most of strains producing monacolin K corresponded to strains producing red pigment highly and showing more pH changes of liquid media. Monacolin K produced from strains was detected in culture broth as well as mycelia. Any citrinin was not detected in monacolin K producing strains. These results imply that the selection of the strains producing red pigment highly and showing more pH changes in liquid cultivation could be applied for primary screening of Monascus strains for preparation of red mold rice.

Keywords

References

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