Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of age on changes of body composition through caloric restriction in overweight and obese women

과체중 및 비만여성에서 연령이 열량 제한에 의한 체조성 변화에 미치는 영향

  • Yim, Jung-Eun (Department of Food & Nutrition, Changwon National University) ;
  • Kim, Young-Seol (Department of Medical Nutrition, Graduate School of East-west Medical Science) ;
  • Choue, Ryowon (Department of Internal Medicine, Kyung Hee Medical Center)
  • 임정은 (창원대학교 자연과학대학 식품영양학과) ;
  • 김영설 (경희대학교 의과대학 내분비교실) ;
  • 조여원 (경희대학교 동서의학대학원 의학영양학과)
  • Received : 2013.01.18
  • Accepted : 2013.09.25
  • Published : 2013.10.31
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Abstract

Caloric restriction is recognized as one of the best treatment options for obesity, and is associated with changes in body composition. The purpose of this study was to determine the influence of age in caloric restriction in overweight and obese women. In this caloric restriction study, nutrient intake of 61 women was evaluated using food records written by subjects for three days. Body composition and metabolic risk factors were assessed before and after caloric restriction. Blood levels of lipids, glucose, leptin, and adiponectin were measured. Visceral fat and subcutaneous fat were evaluated using bioimpedance analysis. General linear models (GLM) identified the independent effects of age after co-varying baseline weight and difference of energy intake. Weight, fat mass, visceral fat, subcutaneous fat, and blood pressure showed a significant decrease by caloric restriction of 452 kcal/day. The percent changes in weight, visceral fat, and subcutaneous fat were -4.5%, -12.0%, and -8.2%, respectively, after caloric restriction. The percent changes of weight, visceral fat, and subcutaneous fat showed an independent association with age co-varying baseline weight and difference of energy intake. Decreased change in percent of leptin by caloric restriction also showed an association with age. Changes in body composition and leptin by caloric restriction showed an independent association with age. This may indicate greater difficulty in achievement of change of body composition as well as greater obesity-related metabolic risk with aging. Therefore, caloric restriction considering age should be recommended for effective dietary treatment in overweight or obese women.

본 연구는 만 19~60세의 BMI $23kg/m^2$ 이상 여성 61명을 대상으로 12 주간 열량 섭취 제한 시 체중 감량에 영향을 미치는 요인을 분석하고 이들의 상관성을 알아보고자 하였다. 12주간의 열량 섭취 제한으로 하루 평균 451.9 kcal가 감소하였고 열량 제한 후 체중은 평균 4.5% 감소하였고, 내장지방량은 11.9%, 피하지방량은 8.2% 감소하였으며, 혈압도 유의하게 감소하였다 (p < 0.01). 혈액지표 중 GPT 농도는 감소하였으며 (p < 0.05), 아디포넥틴 농도는 증가하였다 (p < 0.01). 연령이 증가함에 따라 섭취 열량 감소량이 낮게 나타났다 (r = 0.31, p = 0.02). 젊은 연령에서 열량 섭취량 감소가 컸으며, 연령이 증가할수록 열량 섭취량 감소가 낮게 나타났다. 연령은 독립적으로 신체 조성 변화와 유의한 관련이 있었으며 (p < 0.05), 연령이 증가함에 따라 열량 섭취 제한에 따른 체중 및 내장지방과 피하지방의 감소량이 낮았으며, 특히, 내장지방 감소량이 낮게 나타났다 (p < 0.05). 또한, 연령이 증가함에 따라 열량 섭취 제한에 따른 렙틴 농도 감소량도 낮았다 (p < 0.05).

Keywords

References

  1. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea health statistics 2009: Korea National Health and Nutrition Examination Survey (KNHANESIV-3). Seoul: Ministry of Health and Welfare; 2010
  2. Ogden CL, Carroll MD. Prevalence of overweight, obesity, and extreme obesity among adults: United States, trends 1960-1962 through 2007-2008. Atlanta (GA): National Center for Health Statistics; 2010
  3. Laddu D, Dow C, Hingle M, Thomson C, Going S. A review of evidence-based strategies to treat obesity in adults. Nutr Clin Pract 2011; 26(5): 512-525 https://doi.org/10.1177/0884533611418335
  4. Swinburn B, Egger G. Preventive strategies against weight gain and obesity. Obes Rev 2002; 3(4): 289-301 https://doi.org/10.1046/j.1467-789X.2002.00082.x
  5. Ahmadi N, Eshaghian S, Huizenga R, Sosnin K, Ebrahimi R, Siegel R. Effects of intense exercise and moderate caloric restriction on cardiovascular risk factors and inflammation. Am J Med 2011; 124(10): 978-982 https://doi.org/10.1016/j.amjmed.2011.02.032
  6. Kim MS, Choi MS, Kim KN. Effect of nutritional education and exercise intervention on reducing and maintaining weight in obese women. Korean J Community Nutr 2007; 12(1): 80-89
  7. Schwarz NA, Rigby BR, La Bounty P, Shelmadine B, Bowden RG. A review of weight control strategies and their effects on the regulation of hormonal balance. J Nutr Metab 2011; 2011: 237932
  8. Arrebola E, Gomez-Candela C, Fernandez-Fernandez C, Loria V, Munoz-Perez E, Bermejo LM. Evaluation of a lifestyle modification program for treatment of overweight and nonmorbid obesity in primary healthcare and its influence on health-related quality of life. Nutr Clin Pract 2011; 26(3): 316-321 https://doi.org/10.1177/0884533611405993
  9. Kim YY, Lee IH, Lee IS, Choue RW. Effect of 8 weeks of low calorie diet on body composition and blood parameters in the people with BMI greater than 23 kg/m2. J East Asian Soc Diet Life 2008; 18(5): 725-731
  10. Lee J, Lee H, Yim J, Kim Y, Choue R. Effects of medical nutrition therapy on changes of anthropometric measurements, dietary pattern and blood parameters in over weight or obese women. Korean J Nutr 2005; 38(6): 432-444
  11. Choi IS, Kim KA, Yim JE, Kim YS. Calorie restriction and obesity under the regulation of SIRT1. Korean J Obes 2011; 20(4): 170-176 https://doi.org/10.7570/kjo.2011.20.4.170
  12. Finkler E, Heymsfield SB, St-Onge MP. Rate of weight loss can be predicted by patient characteristics and intervention strategies. J Acad Nutr Diet 2012; 112(1): 75-80 https://doi.org/10.1016/j.jada.2011.08.034
  13. Kim S, Choue R, Yim J, Kim Y. Effects of Apo E polymorphisms and dietary counseling on the levels of plasma lipids in hyperlipidemic patients. Korean J Nutr 1998; 31(9): 1411-1421
  14. Choue R, Yim J, Kim S, Kim Y. Effects of nutrition therapy and drug treatment on the blood lipid levels in patients with hyperlipidemia according to genetic polymorphism of Apo CIII. Korean J Nutr 2000; 33(8): 813-823
  15. St-Onge MP, Gallagher D. Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition 2010; 26(2): 152-155 https://doi.org/10.1016/j.nut.2009.07.004
  16. Amati F, Pennant M, Azuma K, Dube JJ, Toledo FG, Rossi AP, Kelley DE, Goodpaster BH. Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance. Obesity (Silver Spring) 2012; 20(5): 1115-1117 https://doi.org/10.1038/oby.2011.401
  17. Yoon JH. Resistance exercise strategies for sarcopenic obesity in elderly people. Korean J Obes 2012; 21(1): 5-10 https://doi.org/10.7570/kjo.2012.21.1.5
  18. Shin HM, Jee SH, Kim JH, Kim MR. The influence on cardiovascular mortality of the metabolic syndrome in Korean postmenopausal women. J Korean Soc Menopause 2012; 18(1): 6-14 https://doi.org/10.6118/jksm.2012.18.1.6
  19. Ahn HJ, Cho YO, Kwon HR, Ku YH, Koo BK, Han KA, Min KW. The effects of low-calorie diets on abdominal visceral fat, muscle mass, and dietary quality in obese type 2 diabetic subjects. Korean Diabetes J 2009; 33(6): 526-536 https://doi.org/10.4093/kdj.2009.33.6.526
  20. Seo YW, Lee HJ, Yun KE, Park HS. Energy intake and resting energy expenditure of middle-aged obese Korean women. Korean J Obes 2009; 18(1): 31-37
  21. Son SM, Kim HJ. Effect of 12-week low calorie diet and behavior modification on the anthropomeric indices and biochemical nutritional status of obese woman. Korean J Community Nutr 2005; 10(4): 525-535
  22. Choi MS. Effects of nutrition education and exercise intervention on health and diet quality of middle-aged women. Korean J Nutr 2009; 42(1): 48-58
  23. Kim HK, Kim MJ. Effects of weight control program on dietary habits and blood composition in obese middle-aged women. Korean J Nutr 2010; 43(3): 273-284 https://doi.org/10.4163/kjn.2010.43.3.273
  24. Gasteyger C, Larsen TM, Vercruysse F, Pedersen D, Toubro S, Astrup A. Visceral fat loss induced by a low-calorie diet: a direct comparison between women and men. Diabetes Obes Metab 2009; 11(6): 596-602 https://doi.org/10.1111/j.1463-1326.2008.01025.x
  25. Kang JH, Kim SW, Park HS, Kim HS. Comparison of clinical usefulness of low-calorie-diet combined with exercise and lowcalorie- diet alone. J Korean Acad Fam Med 1998; 19(2): 167-176
  26. Barone Gibbs B, Kinzel LS, Pettee Gabriel K, Chang YF, Kuller LH. Short- and long-term eating habit modification predicts weight change in overweight, postmenopausal women: results from the WOMAN study. J Acad Nutr Diet 2012; 112(9): 1347-1355, 1355.e1-2 https://doi.org/10.1016/j.jand.2012.06.012
  27. Poehlman ET, Goran MI, Gardner AW, Ades PA, Arciero PJ, Katzman-Rooks SM, Montgomery SM, Toth MJ, Sutherland PT. Determinants of decline in resting metabolic rate in aging females. Am J Physiol 1993; 264(3 Pt 1): E450-E455
  28. Yeo E. Menopause, aging and obesity. J Korean Soc Study Obes 2002; 11(3): 289-298
  29. Tchernof A, Després JP. Sex steroid hormones, sex hormonebinding globulin, and obesity in men and women. Horm Metab Res 2000; 32(11-12): 526-536 https://doi.org/10.1055/s-2007-978681
  30. Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR. Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond) 2008; 32(6): 949-958 https://doi.org/10.1038/ijo.2008.25
  31. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 2003; 88(6): 2404-2411 https://doi.org/10.1210/jc.2003-030242
  32. Park JA, Kim KJ, Kim JH, Park YS, Koo J, Yoon JS. A comparison of the resting energy expenditure of Korean adults using indirect calorimetry. Korean J Community Nutr 2003; 8(6): 993-1000
  33. Suk MH, Shin YA, Lim KI. The effects of age and obesity on energy expenditure and fat oxidation according to exercise intensity in women. J Korean Phys Edu Assoc Girls Women 2010; 24(3): 213-223
  34. Lee KY, Jang MR, Kim EK, Huh KB. A study on body fat distribution in obese human -Specially related to risk factors in degenerated diseases. Korean J Nutr 1991; 24(3): 157-165
  35. Moon SJ, Kim HS, Kim JH, Park GS, You YH. The effect of weight control on obese women. Korean J Nutr 1995; 28(8): 759-770
  36. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV. Leptin: the tale of an obesity gene. Diabetes 1996; 45(11): 1455-1462 https://doi.org/10.2337/diab.45.11.1455
  37. Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 1998; 67(6): 370-376 https://doi.org/10.1159/000054335
  38. Duggal PS, Van Der Hoek KH, Milner CR, Ryan NK, Armstrong DT, Magoffin DA, Norman RJ. The in vivo and in vitro effects of exogenous leptin on ovulation in the rat. Endocrinology 2000; 141(6): 1971-1976
  39. Agarwal SK, Vogel K, Weitsman SR, Magoffin DA. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J Clin Endocrinol Metab 1999; 84(3): 1072-1076
  40. Lee SY, Choi SH, Kim YJ. Impact of weight change on hepatic markers in overweight, middle-aged patients. J Korean Soc Study Obes 2002; 11(4): 362-368
  41. Motoshima H, Wu X, Sinha MK, Hardy VE, Rosato EL, Barbot DJ, Rosato FE, Goldstein BJ. Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 2002; 87(12): 5662-5667 https://doi.org/10.1210/jc.2002-020635
  42. Kamari Y, Grossman E, Oron-Herman M, Peleg E, Shabtay Z, Shamiss A, Sharabi Y. Metabolic stress with a high carbohydrate diet increases adiponectin levels. Horm Metab Res 2007; 39(5): 384-388 https://doi.org/10.1055/s-2007-976534
  43. Arvidsson E, Viguerie N, Andersson I, Verdich C, Langin D, Arner P. Effects of different hypocaloric diets on protein secretion from adipose tissue of obese women. Diabetes 2004; 53(8): 1966-1971 https://doi.org/10.2337/diabetes.53.8.1966
  44. Kasim-Karakas SE, Tsodikov A, Singh U, Jialal I. Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. Am J Clin Nutr 2006; 83(4): 774-779
  45. Lee MY, Kim JH. Association of serum lipids and dietary intakes with serum adiponectin level in overweight and obese Korean women. Korean J Community Nutr 2010; 15(1): 27-35

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