The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Antioxidant Activity of Rosa rugosa Thunberg and Effect on Serum Lipid Level in High Fat Diet-induced Mice

해당화 열매 추출 분말의 항산화 활성과 고지방 식이로 유도된 Mice의 혈청지질 수준에 미치는 영향

  • Choi, Kyung-Soon (Dept. of Food and Nutrition, Sahmyook University) ;
  • Kim, Yong-Hwan (Dept. of Food Science & Biotechnology, Kyonggi University) ;
  • Lee, Ki-Won (The Research Institute of Basic Science, Kyonggi University) ;
  • Shin, Kyung-Ok (Dept. of Food and Nutrition, Sahmyook University)
  • 최경순 (삼육대학교 식품영양학과) ;
  • 김용환 (경기대학교 식품생물공학과) ;
  • 이기원 (경기대학교 기초과학연구소) ;
  • 신경옥 (삼육대학교 식품영양학과)
  • Received : 2015.02.05
  • Accepted : 2015.04.20
  • Published : 2015.04.30
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Abstract

Since Korean ancient times, powder of Rosa rugosa Thunberg has been used as a folk remedy. This study was conducted to verify the effects of Rosa rugosa Thunberg powder on in vitro antioxidant properties and serum lipid levels of high-fat diet-induced mice from a nutritional viewpoint. In the case of Rosa rugosa Thunberg powders, measurement of TPC, ABTS radical scavenging activity of trolox, DPPH radical scavenging activity, and measured value of FRAP were higher in ethanol extract than water extracts. For LDL-cholesterol concentration, mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a high numerical value compared with other groups (p<0.05). When testing for triglyceride concentrations in blood, mice fed 10% and 20% powder of Rosa rugosa Thunberg with high-fat diets showed the lowest numerical values (p<0.05). When testing for blood insulin concentrations, the high-fat diet group showed higher levels than compared to the control group (p<0.05). When testing for blood leptin concentrations, the high-fat diet group was $5.88{\pm}3.53ng/dL$, whereas mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a blood leptin level of $10.36{\pm}5.96ng/dL$ (p<0.05). Therefore, results prove that powder of Rosa rugosa Thunberg reduces triglyceride concentrations in the blood, and could be used as an excellent natural antioxidant in the future.

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References

  1. Cho WK, Choi JH. 2007. Effect of pyroligneous liquor on lipid metabolism in serum of CD rats. Korean J Nutr 40:24-30
  2. Choi KS, Kim YH, Kim SO, Shin KO, Chung KH. 2013. Effect of intake of sponge gourd (Luffa cylindrica) seed oil and yukdomok (Chionanthus retusa L.) seed oil on lipid levels of blood and organs of a mice. Food Sci Biotechnol 22:757-763 https://doi.org/10.1007/s10068-013-0142-5
  3. Choi YH, Kim MJ, Lee HS, Changxu Hu, Kwak SS. 1997. Antioxidants in leaves of Rosa rugosa. Korean J Pharmacogn 28:179-184
  4. Considine RV, Caro JF. 1996. Leptin: Genes, concepts and clinical perspective. Horm Res 46:249-256 https://doi.org/10.1159/000185096
  5. Guerre-Millo M. 1997. Regulation of ob gene and overexpression in obesity. Biomed Pharmacother 51:318-323 https://doi.org/10.1016/S0753-3322(97)88048-1
  6. Han SY, Park JC, Choi JS. 1987. Isolation of (+)-catechin from the roots of Rosa rugosa. Korean J Pharmacogn 18:177-179
  7. Havel PJ. 2000. Role of adipose tissue in body-weight regulation: Mechanisms regulating leptin production and energy balance. Proc Nutr Soc 59:359-371 https://doi.org/10.1017/S0029665100000410
  8. Hong KH, Kang SA, Kim SH, Choue RW. 2001. Effects of high fat diet on leptin and insulin level and brown adipose tissue UCP 1 expression in rats. Korean J Nutr 34:865-871
  9. Jang JY, Choi HJ. 2003. Effects of Artemisia iwayomogi oligosaccharide on the blood lipids, abdominal adipose tissues and leptin levels in the obese rats. Korean J Nutr 36:437-445
  10. Johnson-Johnson Diagnostics. 2001. The reference intervals in biochemical analyte of laboratory animal. Ortho Clinical Diagnostics, Johnson-Johnson Co, New York. p13.
  11. Jung HJ, Nam JH, Choi J, Lee KT, Park HJ. 2005. 19 alphahydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa. Biol Pharm Bull 28:101-104 https://doi.org/10.1248/bpb.28.101
  12. Kang KJ, Lim SJ, Jeong JG, Han HK, Choi SS, Kim MH, Kwon SY. 2003. Effects of wax guard on weight, triglyceride, leptin and fat cell size in rats fed on a high fat diet. Korean J Nutr 36:446-451
  13. Kang MH, Lee JH, Lee JS, Kim JH, Chung HK. 2004. Effects of acon supplementation on lipid profiles and antioxidant enzyme activities in high fat diet-induced obese rats. Korean J Nutr 37:169-175
  14. Kang SC, Lim JD, Lee JC, Park HJ, Kang NS, Sohn EH. 2010. Effects of fructus and semen from Rosa rugosa on osteoimmune cells. Korean J Plant Res 23:157-164
  15. Kim JH, Park YS. 1986. A study on the chemical constituents of Rosa rugosa roots. Korean J Pharmacogn 17:35-38
  16. Kim MJ, Kim KE, Shin KH, Heo K, Cho DH, Park CH, Yu CY. 2001. Comparison of antioxidative activities from different organs of Rosa rugosa Thunb. Korean J Medicinal Crop Sci 9:40-44
  17. Korea Food and Drug Administration. 2003. Food Code. Korean Foods Ind. Asso. Seoul, Korea
  18. Lee JY, Lee JH, Ki GY, Kim ST, Han TH. 2011. Improvement of seed germination in Rosa rugosa. Korean J Hort Sci Technol 29:352-357
  19. Martinek RG. 1972. A rapid ultraviolent spectrophotometric lactic dehydrogenase assay. Clin Chem Acta 40:91-99 https://doi.org/10.1016/0009-8981(72)90254-9
  20. Mistry AM, Swick AG, Romsos DR. 1997. Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice. J Nutr 127:2065-2072
  21. Okawa M. 2005. Study on the antioxidative and antiproliferative activity of the polyphenol contained some functional foods. Pharmaceutical Bul Fukuoka Univ 5:1-12
  22. Park BJ. 2008. Isolation of main component and antioxidant activities on the stem and root of Rosa rugosa. Korean J Plant Res 21:402-407
  23. Park HJ, Lim SC, Kim DH, Lee JH, Kang HO, Choi JW. 2005a. Effect of the Rosa rugosa extract on the rat with the alcohol-salicylate-induced gastropathy. Korean J Pharmacogn 36:38-43
  24. Park HJ, Nam JH, Jung HJ, Lee MS, Lee KT, Jung MH, Choi JW. 2005b. Inhibitory effect of euscaphic acid and tormentic acid from the roots of Rosa rugosa on high fat diet-induced obesity in the rat. Korean J Pharmacogn 36:324-331
  25. Park JC, Young HS, Lee SH. 1993. A tannin compound isolated from the underground part of Rosa rugosa Thunb. Korean J Pharmacogn 24:319-321
  26. Pulido R, Bravo L, Saura-Calixto F. 2000. Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J Agric Food Chem 48:3396-3402 https://doi.org/10.1021/jf9913458
  27. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231-1237 https://doi.org/10.1016/S0891-5849(98)00315-3
  28. Reitman S, Frankel S. 1957. Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56-63 https://doi.org/10.1093/ajcp/28.1.56
  29. Rudel L, Morris MD. 1973. Determination of cholesterol using o-phthalaldehyde. J Lipid Res 14:364-366
  30. Sanchez-Moreno C, Larrauri JA, Saura-Calixto FA. 1998. Procedure to measure the antiradical efficiency of polyphenols. J Sci Food Agric 76:270-276 https://doi.org/10.1002/(SICI)1097-0010(199802)76:2<270::AID-JSFA945>3.0.CO;2-9
  31. Sheo HJ. 2001. Effects of perilla oil on the levels of plasma lipids and other biochemical parameters in rats. J Korean Soc Food Sci Nutr 30:703-709
  32. Sheo HJ, Sheo YS. 2002. Adverse effects of the megadose perilla oil on the rats metabolism. J Korean Soc Food Sci Nutr 31:277-283 https://doi.org/10.3746/jkfn.2002.31.2.277
  33. Singleton VL, Rossi JAJ. 1965. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Viticult 16:144-158

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