DOI QR코드

DOI QR Code

Exposure Levels and Influence Factors of PAHs and Benzene Metabolites in the Urine of the General Korean Adult Population - Korean National Environmental Health Survey (2009-2017) -

우리나라 성인의 체내 PAHs 및 벤젠 대사체 노출수준 및 영향요인 분석 - 국민환경보건 기초조사(2009-2017) -

  • Kwon, Young Min (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Joo, Youngkyung (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Park, Choong-Hee (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Kim, Sung Yeon (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Choi, Kyungho (Department of Environmental Health Sciences, Graduate School of Public Health, Seoul National University) ;
  • Lee, Chulwoo (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Yu, Seung Do (Environmental Health Research Department, National Institute of Environmental Research) ;
  • Yoo, Jiyoung (Environmental Health Research Department, National Institute of Environmental Research)
  • 권영민 (국립환경과학원 환경보건연구과) ;
  • 주영경 (국립환경과학원 환경보건연구과) ;
  • 박충희 (국립환경과학원 환경보건연구과) ;
  • 김성연 (국립환경과학원 환경보건연구과) ;
  • 최경호 (서울대학교 보건대학원 환경보건학과) ;
  • 이철우 (국립환경과학원 환경보건연구과) ;
  • 유승도 (국립환경과학원 환경보건연구과) ;
  • 유지영 (국립환경과학원 환경보건연구과)
  • Received : 2019.09.17
  • Accepted : 2019.10.04
  • Published : 2019.10.31

Abstract

Objectives: The aim of this study is to compare exposure levels of PAHs and benzene metabolites in the urine of nationally representative adults in Korea and identify exposure factors in relation to questionnaire results. Methods: The study analyzed PAHs and benzene metabolites in the urine of adults aged 19 and older recruited in Cycles 1-3 of the Korean National Environmental Health Survey (KoNEHS). Participants were administered questionnaires on demographic characteristics, lifestyle, and dietary habits to identify the association with exposure levels to environmental chemicals. Results: 1-hydroxypyrene and t,t-muconic acid levels in this study were higher than those in large-scale biomonitoring conducted in other countries (the US and Canada), while 2-hydroxynaphthalene levels were lower. Most environmental chemicals exhibited significant differences depending on gender and age, and exposure levels tended to increase with grilled food intake. In addition, variables such as smoking, distance between home and a road, travelling on public transportation, and ventilation time had a significant effect on exposure to environmental chemicals. Conclusions: The importance of this study lies in utilizing the representative results of KoNEHS, large scale biomonitoring conducted in Korea over roughly ten years. Variables including smoking and roasted food intake were found to affect exposure to PAHs and benzene, which can be used to establish baseline exposure levels of environmental chemicals in Korea.

Keywords

References

  1. Park CH, Yu SD. Status and Perspects of the Korean National Environmental Health Survey (KoNEHS). J Environ Health Sci. 2014; 40(1): 1-9.
  2. Centers for Disease Control and Prevention. Fourth National Report on Human Exposure to Environmental Chemicals, Update Tables. Washington, DC: CDC; 2015.
  3. Health Canada. Fourth Report on Human Biomonitoring of Environmental Chemicals in Canada, Results of the Canadian Health Measures Survey Cycle 4 (2014-2015). Ottawa: Health Canada; 2017.
  4. Becker K, Kaus S, Krause C, Lepom P, Schulz C, Seiwert M, Seifert B, et al. German Environmental Survey 1998 (GerES III): environmental pollutants in blood of the German population. Int. J. Hyg. Environ. Health. 2002; 205: 297-308. https://doi.org/10.1078/1438-4639-00155
  5. Ministry of Food and Drug Safety. Risk profile-Polycyclic aromatic hydrocarbons, 1st ed. Cheongju: Ministry of Food and Drug Safety; 2010.
  6. Lagorio S, Forastiere F, Lipsett M, Menichini E, et al. Air pollution from traffic and the risk of tumors. Ann. Ist. Super. Sanita. 2000; 36: 311-329.
  7. Jacob J, Seidei A. Biomonitoring of polycyclic aromatic hydrocarbons in human urine. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2002; 778: 31-47. https://doi.org/10.1016/S0378-4347(01)00467-4
  8. American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs, 7th ed. Ohio: ACGIH; 2001.
  9. Ministry of Food and Drug Safety. Risk profile-Benzene, 1st ed. Cheongju: Ministry of Food and Drug Safety; 2010.
  10. OH HC, KIM CN, Won JU, KIM HS, et al. Availability of trans, trans-muconic acid as a biomarker for exposure to low concentrations of benzene. J Korean Soc Occup Environ Hyg. 2004; 14(2): 155-164.
  11. Medeiros A, Bird M, Witz G, et al. Potential biomarkers of benzene exposure. J Toxicol Environ Health A. 1997; 51: 519-539. https://doi.org/10.1080/00984109708984042
  12. Amodio-Cocchieri R, Prete UD, Cirillo T, Agozzino E, Scarano G, et al. Evaluation of benzene exposure in children living in Campania (Italy) by urinary trans, trans-muconic acid assay. J Toxicol Environ Health A. 2001; 63: 79-87. https://doi.org/10.1080/15287390151126388
  13. Scherer G, Renner T, Meger M, et al. Analysis and evaluation of trans,trans-muconic acid as a biomarker for benzene exposure. J Chromatogr B Biomed Sci Appl. 1998; 717: 179-199. https://doi.org/10.1016/S0378-4347(98)00065-6
  14. American Conference of Governmental Industrial Hygienists. Threshold limit values and biological exposure indices for 2010-2011, Cincinnati (OH): ACGIH; 2011.
  15. Yu SD, Park KH, Kim HJ, Lee YM. Mannual for Laboratory Procedures on The First Stage Korean National Environmental Health Survey (Organic compounds), 1st ed. Incheon: National Institute of Environmental Research; 2012. p. 71-82.
  16. KIM SJ, Paek YW, Kwon YM, Choi WH, et al. Mannual for Laboratory Procedures on The Second Stage Korean National Environmental Health Survey (Organic compounds), 2nd ed. Incheon: National Institute of Environmental Research; 2015. p. 92-111.
  17. Yoo JY, Kim SY, Kwon YM, Jung SK, et al. Mannual for Laboratory Procedures on The Third Stage Korean National Environmental Health Survey (Organic compounds), 3rd ed. Incheon: National Institute of Environmental Research; 2018. p. 93-107.
  18. Schulz C, Angerer J, Ewers U, Heudorf U, Wilhelm M, et al. Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German Environmental Survey on Children 2003-2006. Int J Hyg Environ Health. 2009; 212(6): 637-647. https://doi.org/10.1016/j.ijheh.2009.05.003
  19. Aquilina NJ, Delgado-Saborit JM, Meddings C, Baker S, Harrison RM, Jacob III P, Wilson M, Yu L, Duan M, Benowitz NL, et al. Environmental and biological monitoring of exposures to PAHs and ETS in the general population. Environ Int. 2010; 36(7): 763-771. https://doi.org/10.1016/j.envint.2010.05.015
  20. Kho YL, Lee EH. Comparison of Concentration of Urinary Metabolites of PAHs from Smokers and Nonsmokers. J Environ Health Sci, 2011; 37(6): 474-481.
  21. Kim KM, Eom SY, Yim DH, Moon SI, Kim YD, Kim H, et al. Urinary Hippuric Acid and trans,trans-Muconic Acid Levels According to Commuting Mode and Duration, Residential Environment, and Intake of Preservative-Added Foods and Beverages in University Students. Korean J Occup Environ Med. 2012; 24(1): 61-71. https://doi.org/10.35371/kjoem.2012.24.1.61
  22. Jalai A, Ramezani Z, Ebrahim K, et al. Urinary Trans, Trans-Muconic Acid is Not a Reliable Biomarker for Low-level Environmental and Occupational Benzene Exposures. Safety and Health at Work. 2017; 8: 220-225. https://doi.org/10.1016/j.shaw.2016.09.004
  23. Lee KH, Li ZM, Cho SH, Kwon HJ, Kang DH, et al. Urinary PAH metabolites as biomarkers of environmental PAHs exposure. J Toxicol? Pub Health. 2007; 23(1): 39-46.
  24. Lee BH, An YJ, Park DY, Byun GY, Kim KD, et al. Characteristics of PAH Occurrence during Meat Cooking, Journal of Environmental Science International. 2016; 25(11): 1459-1466. https://doi.org/10.5322/JESI.2016.25.11.1459
  25. Hu SJ, Jin SH, Lee KH, Choi DM, et al. Dertermination of Polycyclic aromatic hydrocarbons in processed foods. Analytical Science & Technology. 2010; 23(2): 196-204. https://doi.org/10.5806/AST.2010.23.2.196
  26. European Commission. Human Exposure Characterization of Chemical Substances, quantification of exposure routes (HEXPOC), 1st ed. Bruxelles: European Commission; 2005.
  27. Ministry of Food and Drug Safety. Survey of Benzene in Food, 1st ed. Cheongju: Ministry of Food and Drug Safety; 2013. p. 8-9.
  28. Kim KM, Eom SY, Yim DH, Moon SI, Kim YD, Kim H, et al. Urinary Hippuric Acid and trans, trans-Muconic Acid Levels According to Commuting Mode and Duration, Residential Environment, and Intake of Preservative-Added Foods and Beverages in University Students. Korean. J Occup Environ Med 2012; 24(1): 61-71. https://doi.org/10.35371/kjoem.2012.24.1.61
  29. Castro D. Sleza K, Delerue_Matos C, Alvim-Ferraz MC, Morais S, Pereira MC, et al. Contribution of traffic and tabacco smoke in the distribution of polycyclic aromatic hydrocarbons on outdoor and indoor PM2.5. Global Nest Journal. 2010; 12: 3-11. https://doi.org/10.30955/gnj.000683
  30. Lee TH, Kim YS, Son BS, et al. An assessment of Korean housewives exposured to polycyclic aromatic hydrocarbons (PAHs) in indoor air. Journal of the Environmental Sciences. 2007; 16(3): 323-331. https://doi.org/10.5322/JES.2007.16.3.323
  31. Jo WK, Lee JH. In-vehicle levels of naphthalene and monocyclic aromatic compounds according to vehicle type. Environ Eng Res. 2009; 14(3): 180-185. https://doi.org/10.4491/eer.2009.14.3.180
  32. Bakhtiari R, Hadei M, Hopke PK, Shahsavani A, Rastkari N, Kermani M, Yarahmadi M, Ghaderpoori A, et al. Investigation of in-cabin volitile organic compounds (VOCs) in taxi; influence of vehicle's age, model, fuel, and refueling. Environ pollution. 2018; 237: 248-355.
  33. Jongeneelen FJ. Benchmark guideline for urinary 1-hydroxypyrene as biomarker of occupational exposure ro Polycyclic aromatic hydrocarbons. Ann Occup Hyg. 2001; 45(1): 3-13. https://doi.org/10.1016/S0003-4878(00)00009-0
  34. Wheeler AJ, Dobbin NA, Heroux ME, Fisher M, Sun L, Khoury CE, et al. Urinary and breast milk biomarkers to assess exposure to naphthalene in pregnant women: an investigation of personal and indoor air sources. Environmental Health. 2014; 13: 30. https://doi.org/10.1186/1476-069X-13-30