Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Study on Antioxidant and Cytotoxic Activities in Ethanol Extract from Prunus mume

오매 에탄올 추출물의 항산화 활성 및 항암 활성 연구

  • Jeon, Yeon-Hee (Dept. of Food Science and Nutrition, Kyungpook National University) ;
  • Kwon, Ji-Eun (Dept. of Food Science and Nutrition, Kyungpook National University) ;
  • Kim, Mee-Ra (Dept. of Food Science and Nutrition, Center for Beautiful Aging, Kyungpook National University)
  • 전연희 (경북대학교 식품영양학과) ;
  • 권지은 (경북대학교 식품영양학과) ;
  • 김미라 (경북대학교 식품영양학과, 장수생활과학연구소)
  • Received : 2010.09.09
  • Accepted : 2010.10.21
  • Published : 2010.10.31
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Abstract

Prunus mume is well known contain many functional materials that play beneficial roles in the human body. Studies have found that many organic acids and polyphenol compounds exist in Prunus mume. In this study, content of total polyphenols and flavonoids, antioxidative activity and cytotoxicity of ethanol extract from Prunus mume were measured Contents of total polyphenolic and total flavonoid compounds in ethanol extract from Prunus mume were 16.92 mg/g and 59.95 mg/g, respectively. The $IC_{50}$ of ethanol extract from Prunus mume were $237.72 {\mu}g$/assay and $239.58 {\mu}g$/assay by DPPH and ABTS radical cation scavenging test, respectively. Additionally, ferric ion reducing antioxidant power (FRAP) value of ethanol extract from Prunus mume was 0.94 mM ($FeSO_4$ eq.) by $800 {\mu}g$/assay. Cytotoxicity of Prunus mume against five kinds of cancer cell lines increased as the extract concentration increased Especially, cytotoxicity of the ethanol extract against A-549 (lung cancer line) was higher than that against any other cancer cell line by both MTT and SRB assay. These results show that ethanol extract of Prunus mume has considerably high antioxidative and cytotoxic activities.

Keywords

References

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